/  Rosario - Santa Fe - Argentina

 
 
     

 


 

Prof. Dr. Hugo Tanno
 

Profesor Titular de la Cátedra de Gastroenterología y Hepatología. Hospital Provincial del Centenario. Facultad de Ciencias Médicas. Universidad Nacional de Rosario

Director de la Carrera de Post-Grado en Gastroenterología. Facultad de Medicina de la Universidad Nacional de Rosario

Miembro correspondiente Nacional de la Academia de Medicina de Buenos Aires

Ex - Presidente de la Asociación Latinoamericana para el Estudio de las Enfermedades del Hígado.

 

 

 

Hepatitis C: Cambios potenciales del esquema actual de tratamiento

Prof. Dr. Hugo Tanno
 

Bibliografía

  1. Hoofnagle JH, Mullen KD, Jones DB, et al. Treatment of chronic non-A, non-B hepatitis with recombinant human alpha interferon. N.Engl.J.Med 1986; 315: 1575-1578.

  2. Di Bisceglie AM, Martin P, Kassianides C, et al. Recombinant interferon alpha therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N.Engl.J.Med 1989; 321: 1506-1510.

  3. Poynard T, Leroy V, Cohard M, et al. Meta-analysis of interferon randomized trials in the treatment of viral hepatitis C : effects of dose and duration. Hepatology 1996; 24: 778-789.

  4. McHutchison JG, Gordon SC, Schiff ER, et al. Interferon alpha-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N.Engl.J.Med 1998; 339: 1485-1492.

  5. Poynard T, Marcellin P, Lee SS, et al. Randomized trial of interferon alpha 2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha 2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. Lancet 1998; 352: 1426-1432.

  6. Manns MP, McHutchison JG, Gordon SC, et al. Peginterferon alpha-2b plus ribavirin compared with interferon alpha-2b plus ribavirin for initial treatment of chronic hepatitis C : a randomized trial. Lancet 2001; 358: 958-965.

  7. Fried MW, Shiffman ML, Reddy KR, et al. Combination of Peginterferon alpha-2a plus ribavirin in patients with chronic hepatitis C virus infection. N.Engl.J.Med 2002; 347: 975-982.

  8. Hadziyannis SJ, Sette H Jr, Morgan TR, et al. Peginterferon-alpha-2a and ribavirin combination therapy in chronic hepatitis C. A randomized study of duration and ribavirin dose. Ann. Intern.Med 2004; 140: 346-355.

  9. Buti M, San Miguel R, Brosa M, et al. Estimating the impact of hepatitis C virus therapy on future liver-related morbidity, mortality and costs related to chronic hepatitis C. J.Hepatol 2005; 42: 639-645.

  10. Layden-Almer JE, Layden TJ. Viral kinetics in hepatitis C virus : special patient populations. Semin Liver Dis 2003; 23(Suppl.1): 29-33.

  11. Layden-Almer JE, Ribeiro RM, Wiley T, Perelson AS, Layden TJ. Viral dynamics and response differences in HCV- infected African American and white patients treated with IFN and ribavirin. Hepatology 2003; 37: 1343-1350.

  12. Davis GL. Monitoring of viral levels during therapy of hepatitis C. Hepatology 2002; 36: S145-S151.

  13. Ferenci P. Predictors of response to therapy for chronic hepatitis C. Sem.L.Dis 2004; 24 (Suppl.2): 25-31.

  14. Davis GL, Lau JY. Factors predictive of a beneficial response to therapy of hepatitis C. Hepatology 1997; 26: 122S-127S.

  15. Poynard T, McHutchison J, Goodman Z, et al. Is an a la carte combination interferon alpha-2b plus ribavirin regimen possible for the first line treatment in patients with chronic hepatitis C ? Hepatology 2000; 31: 211-218.

  16. Lee SS, Heathcote EJ, Reddy KR, et al. Prognostic factors and early predictability of sustained viral response with peginterferon alpha-2a (40 KD). J.Hepatol 2002; 37: 500-506.

  17. Pawlotsky JM. Mechanism of antiviral treatment efficacy and failure in chronic hepatitis C. Antiviral Res 2003; 59: 1-11.

  18. Farci P, Strazzera R, Alter HJ, et al. Early changes in hepatitis C viral quasispecies during interferon therapy predict the therapeutic outcome. Proc.Natl.Acad.Sci USA 2002; 99: 3081-3086.

  19. Rubbia-Brandt L, Giostra E, Mentha G, Quadri R, negro F. Expression of liver steatosis in hepatitis C virus infection and pattern of response to alpha interferon. J.Hepatol 2001; 35: 307.

  20. Cacciola I, Pollicino T, Squadrito G, et al. Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N.Engl.J.Med 1999; 341: 22-26.

  21. Soriano V, Sulkowski M, Bergin C, et al. Care of patients with chronic hepatitis C and HIV co-infection : recommendations from the HIV-HCV International Panel. AIDS 2002; 16: 813-828.

  22. Bekkering FC, Brouwer JT, Leroux-Roels G, et al. Ultra rapid hepatitis C virus clearance by daily high-dose interferon in non-responders to standard therapy. J. Hepatol 1998; 28: 960-964.

  23. Neumann AU, Lam NP, Dahari H, et al. Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy. Science 1998; 282: 103-107.

  24. Neumann AU, Lam NP, Dahari H, et al. Differences in viral dynamics between genotypes 1 and 2 of Hepatitis C virus.J. Infect Dis 2000; 182: 28-35.

  25. Zeuzem S, Herrmann E, Lee JH, et al. Viral kinetics in patients with chronic hepatitis C treated with standard or peginterferon alpha 2a. Gastroenterology 2001; 120: 1438-1447.

  26. Pawlotsky JM. Current and future concepts in hepatitis C therapy.Sem.L.Dis 2005 ; 25 :72-83.

  27. Moreaux X, Poggi C, Chollet L, et al. Eradication du virus de l’hepatite C après 3 mois de traitement par interféron alpha pour une hépatite chronique virale C (letter). Gastroenterol Clin Biol 2001 ; 25 : 715-716.

  28. Hrycewycz N, Sandres K, Barangue K, et al. Guérison d’une hépatite chronique virale C chez un malade non répondeur à l’interféron alpha 2b, après 3 mois de traitement par l’association interféron alpha 2b et ribavirine (letter). Gastroenterol Clin Biol 2001 ; 25 : 1041-1042.

  29. Nousbaum JB, Cadranel JF, Savary O, et al. Sustained virological response after a short course of treatment with interferon and ribavirin in two chronic hepatitis C patients. J.Hepatol 2003; 39: 655-659.

  30. Ferenci P. Predicting the therapeutic response in patients with chronic hepatitis C: the role of viral kinetic studies. J.Antimicrob Chemother 2004; 53: 15-18.

  31. Ferenci P, Fried MW, Shiffman ML, et al. Predicting sustained virological responses in chronic hepatitis C patients treated with peginterferon alfa-2a (40KD)/ ribavirin. J.Hepatol 2005; 43: 425-433.

  32. Dalgard O, Bjoro K, Hellum KB, et al. Treatment with pegylated interferon and ribavirin in HCV infection with genotype 2 or 3 for 14 weeks : a pilot study. Hepatology 2004; 40: 1260-5.

  33. Mangia A, Santoro R, Minerva N, et al. Peginterferon alfa-2b and ribavirin for 12 vs.24 weeks in HCV genotype 2 or 3. N.Engl J.Med 2005; 352: 2609-17.

  34. Zeuzem S, Hulterantz R, Bourliere M, et al. Peginterferon alfa-2b plus ribavirin for treatment of chronic hepatitis C in previously untreated patients infected with HCV genotypes 2 or 3. J.Hepatol 2004; 40: 993-9.

  35. Zeuzem S, Buti M, Ferenci P, et al. Efficacy of 24 weeks treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C infected with genotype 1 and low pretreatment viremia. J.Hepatol 2006; 44: 97-103.

  36. Zeuzem S, Pawlotsky JM, Lukasiewicz E, et al. International, multicenter, randomized, controlled study comparing dynamically individualized versus standard treatment in patients with chronic hepatitis C. J.Hepatol 2005; 43:250-257.

  37. Craxi A, Camma C. Treating patients with HCV genotype 1 and low viraemia: More than meets the eye. J.Hepatol 2006; 44: 4-7.
     

 
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